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Repurposing of drugs targeting the cytokine storm induced by SARS-CoV-2.

ABSTRACT: A cytokine storm is one of the leading causes of acute respiratory distress syndrome (ARDS) and sepsis-associated multiple organ failure in many respiratory viral infections, including severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). The coronavirus disease 2019 (COVID-19) pandemic has caused millions of deaths worldwide, resulting in an urgent need for effective therapeutic interventions. Repurposing immunosuppressive drugs that target cytokines with immunomodulatory properties is a promising approach to counteract SARS-CoV-2-induced ARDS at the infective and post-infective stages. In this minireview, we examine drugs targeting IL-1β, IL-4/IL-13, IL-6 and TNF-α tested in COVID-19 patients.

SUBMITTER: Ng WH

PROVIDER: S-EPMC10953344 | biostudies-literature | 2023 Jan

REPOSITORIES: biostudies-literature

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Repurposing of drugs targeting the cytokine storm induced by SARS-CoV-2.

Ng Wern Hann WH Tang Patrick Chun Hean PCH Mahalingam Suresh S Liu Xiang X

British journal of pharmacology 20221130 2

A cytokine storm is one of the leading causes of acute respiratory distress syndrome (ARDS) and sepsis-associated multiple organ failure in many respiratory viral infections, including severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). The coronavirus disease 2019 (COVID-19) pandemic has caused millions of deaths worldwide, resulting in an urgent need for effective therapeutic interventions. Repurposing immunosuppressive drugs that target cytokines with immunomodulatory properties is ...[more]

PMID: 36394425

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