Ontology highlight
ABSTRACT:
SUBMITTER: Dias F
PROVIDER: S-EPMC7920065 | biostudies-literature | 2021 Feb
REPOSITORIES: biostudies-literature
Dias Francisca F Almeida Cristina C Teixeira Ana Luísa AL Morais Mariana M Medeiros Rui R
Biomedicines 20210216 2
The development and progression of colorectal cancer (CRC) have been associated with genetic and epigenetic alterations and more recently with changes in cell metabolism. Amino acid transporters are key players in tumor development, and it is described that tumor cells upregulate some AA transporters in order to support the increased amino acid (AA) intake to sustain the tumor additional needs for tumor growth and proliferation through the activation of several signaling pathways. LAT1 and ASCT2 ...[more]