Ontology highlight
ABSTRACT:
SUBMITTER: Nishimura K
PROVIDER: S-EPMC7920363 | biostudies-literature | 2021
REPOSITORIES: biostudies-literature
Nishimura Kazuya K Tanaka Tatsuhide T Takemura Shoko S Tatsumi Kouko K Wanaka Akio A
PloS one 20210301 3
Innate immunity is the first line of defense against bacterial infection and is initiated by macrophages. Sorting nexin 25 (SNX25) is an SNX family member and is reported to negatively regulate TGF-β signaling by enhancing TGF receptor degradation. However, few studies have focused on the relationship between SNX25 and the immune system. We knocked down SNX25 expression in macrophages and examined inflammatory cytokine expression, a hallmark of innate immunity, after lipopolysaccharide stimulati ...[more]