Ontology highlight
ABSTRACT:
SUBMITTER: Adamson A
PROVIDER: S-EPMC4935804 | biostudies-literature | 2016 Jul
REPOSITORIES: biostudies-literature
Nature communications 20160706
Cells respond dynamically to pulsatile cytokine stimulation. Here we report that single, or well-spaced pulses of TNFα (>100 min apart) give a high probability of NF-κB activation. However, fewer cells respond to shorter pulse intervals (<100 min) suggesting a heterogeneous refractory state. This refractory state is established in the signal transduction network downstream of TNFR and upstream of IKK, and depends on the level of the NF-κB system negative feedback protein A20. If a second pulse w ...[more]