White matter microstructure relates to motor outcomes in myotonic dystrophy type 1 independently of disease duration and genetic burden.
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ABSTRACT:
SUBMITTER: Koscik TR
PROVIDER: S-EPMC7921687 | biostudies-literature | 2021 Mar
REPOSITORIES: biostudies-literature
Publications
White matter microstructure relates to motor outcomes in myotonic dystrophy type 1 independently of disease duration and genetic burden.
Koscik Timothy R TR van der Plas Ellen E Gutmann Laurie L Cumming Sarah A SA Monckton Darren G DG Magnotta Vincent V Shields Richard K RK Nopoulos Peggy C PC
Scientific reports 20210301 1
Deficits in white matter (WM) integrity and motor symptoms are among the most robust and reproducible features of myotonic dystrophy type 1 (DM1). In the present study, we investigate whether WM integrity, obtained from diffusion-weighted MRI, corresponds to quantifiable motor outcomes (e.g., fine motor skills and grip strength) and patient-reported, subjective motor deficits. Critically, we explore these relationships in the context of other potentially causative variables, including: disease d ...[more]
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