Project description:Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and the ensuing COVID-19 pandemic have caused ∼40 million cases and over 648,000 deaths in the United States alone. Troubling disparities in COVID-19-associated mortality emerged early, with nearly 70% of deaths confined to Black/African-American (AA) patients in some areas, yet targeted studies within this demographic are scant. Multi-omics single-cell analyses of immune profiles from airways and matching blood samples of Black/AA patients revealed low viral load, yet pronounced and persistent pulmonary neutrophilia with advanced features of cytokine release syndrome and acute respiratory distress syndrome (ARDS), including exacerbated production of IL-8, IL-1β, IL-6, and CCL3/4 along with elevated levels of neutrophil elastase and myeloperoxidase. Circulating S100A12+/IFITM2+ mature neutrophils are recruited via the IL-8/CXCR2 axis, which emerges as a potential therapeutic target to reduce pathogenic neutrophilia and constrain ARDS in severe COVID-19.

2022-11-16 | GSE186267 | GEO

Cochlear implantation in patient with Dandy-walker syndrome.

Project description: Not available

| S-EPMC4435434 | biostudies-other

Association of viral load with serum biomakers among COVID-19 cases.

Project description: Not available

| S-EPMC7192122 | biostudies-literature

Fecal viral shedding in COVID-19 patients: Clinical significance, viral load dynamics and survival analysis.

Project description: Not available

| S-EPMC7455175 | biostudies-literature

CD4+ T cell depletion in an untreated HIV type 1-infected human leukocyte antigen-B*5801-positive patient with an undetectable viral load.

Project description: Not available