Ontology highlight
ABSTRACT:
SUBMITTER: Sam PN
PROVIDER: S-EPMC7921845 | biostudies-literature | 2021 Mar
REPOSITORIES: biostudies-literature
Sam Pingdewinde N PN Calzada Elizabeth E Acoba Michelle Grace MG Zhao Tian T Watanabe Yasunori Y Nejatfard Anahita A Trinidad Jonathan C JC Shutt Timothy E TE Neal Sonya E SE Claypool Steven M SM
iScience 20210216 3
Phosphatidylethanolamine (PE) made in mitochondria has long been recognized as an important precursor for phosphatidylcholine production that occurs in the endoplasmic reticulum (ER). Recently, the strict mitochondrial localization of the enzyme that makes PE in the mitochondrion, phosphatidylserine decarboxylase 1 (Psd1), was questioned. Since a dual localization of Psd1 to the ER would have far-reaching implications, we initiated our study to independently re-assess the subcellular distributio ...[more]