Ontology highlight
ABSTRACT:
SUBMITTER: Haas J
PROVIDER: S-EPMC7923201 | biostudies-literature | 2021 Feb
REPOSITORIES: biostudies-literature
Haas Jan J Frese Karen S KS Sedaghat-Hamedani Farbod F Kayvanpour Elham E Tappu Rewati R Nietsch Rouven R Tugrul Oguz Firat OF Wisdom Michael M Dietrich Carsten C Amr Ali A Weis Tanja T Niederdränk Torsten T Murphy Michael P MP Krieg Thomas T Dörr Marcus M Völker Uwe U Fielitz Jens J Frey Norbert N Felix Stephan B SB Keller Andreas A Katus Hugo A HA Meder Benjamin B
International journal of molecular sciences 20210218 4
With more than 25 million people affected, heart failure (HF) is a global threat. As energy production pathways are known to play a pivotal role in HF, we sought here to identify key metabolic changes in ischemic- and non-ischemic HF by using a multi-OMICS approach. Serum metabolites and mRNAseq and epigenetic DNA methylation profiles were analyzed from blood and left ventricular heart biopsy specimens of the same individuals. In total we collected serum from <i>n</i> = 82 patients with Dilated ...[more]