Ontology highlight
ABSTRACT:
SUBMITTER: Uceda AB
PROVIDER: S-EPMC7923443 | biostudies-literature | 2021 Feb
REPOSITORIES: biostudies-literature
Uceda Ana Belén AB Donoso Josefa J Frau Juan J Vilanova Bartolomé B Adrover Miquel M
Antioxidants (Basel, Switzerland) 20210220 2
Frataxin is a mitochondrial protein which deficiency causes Friedreich's ataxia, a cardio-neurodegenerative disease. The lack of frataxin induces the dysregulation of mitochondrial iron homeostasis and oxidative stress, which finally causes the neuronal death. The mechanism through which frataxin regulates the oxidative stress balance is rather complex and poorly understood. While the absence of human (Hfra) and yeast (Yfh1) frataxins turn out cells sensitive to oxidative stress, this does not o ...[more]