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ABSTRACT: Background
While heavy menstrual bleeding (HMB) is a prevalent symptom among women with abnormal uterine bleeding caused by endometrial disorder (AUB-E) seeking gynecologic care, the primary endometrial disorder remains poorly understood.Methods
Five human endometrial samples from women with AUB-E and the age-matched healthy women were selected, respectively. Proteins from the samples were analyzed by a linear ion trap (LTQ)-Orbitrap Elite mass spectrometer based label-free proteomic approach. The purpose protein was validated by western blot and immunohistochemistry staining.Results
A total of 2353 protein groups were quantified under highly stringent criteria with a false discovery rate of ConclusionThe results indicated a novel mechanism for the cause of AUB-E, as down-expression SMC1A potentially regulated the cell cycle progression in endometrial glandular epithelium further led to bleeding.
SUBMITTER: Jia Y
PROVIDER: S-EPMC7923474 | biostudies-literature | 2021 Mar
REPOSITORIES: biostudies-literature
Jia Yingxian Y Luo Jie J Lan Yibing Y Li Chunming C Ma Linjuan L Zhu Xiaoming X Ruan Fei F Zhou Jianhong J
Reproductive biology and endocrinology : RB&E 20210302 1
<h4>Background</h4>While heavy menstrual bleeding (HMB) is a prevalent symptom among women with abnormal uterine bleeding caused by endometrial disorder (AUB-E) seeking gynecologic care, the primary endometrial disorder remains poorly understood.<h4>Methods</h4>Five human endometrial samples from women with AUB-E and the age-matched healthy women were selected, respectively. Proteins from the samples were analyzed by a linear ion trap (LTQ)-Orbitrap Elite mass spectrometer based label-free prote ...[more]