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Isolation and Characterization of Antibacterial Carotane Sesquiterpenes from Artemisia argyi Associated Endophytic Trichoderma virens QA-8.


ABSTRACT: Carotane sesquiterpenes are commonly found in plants but are infrequently reported in the fungal kingdom. Chemical investigation of Trichoderma virens QA-8, an endophytic fungus associated with the inner root tissue of the grown medicinal herb Artemisia argyi H. Lév. and Vaniot, resulted in the isolation and characterization of five new carotane sesquiterpenes trichocarotins I-M (1-5), which have diverse substitution patterns, and seven known related analogues (6-12). The structures of these compounds were established on the basis of a detailed interpretation of their NMR and mass spectroscopic data, and the structures including the relative and absolute configurations of compounds 1-3, 5, 9, and 10 were confirmed by X-ray crystallographic analysis. In the antibacterial assays, all isolates exhibited potent activity against Escherichia coli EMBLC-1, with MIC values ranging from 0.5 to 32 µg/mL, while 7?-hydroxy CAF-603 (7) strongly inhibited Micrococcus luteus QDIO-3 (MIC = 0.5 µg/mL). Structure-activity relationships of these compounds were discussed. The results from this study demonstrate that the endophytic fungus T. virens QA-8 from the planted medicinal herb A. argyi is a rich source of antibacterial carotane sesquiterpenes, and some of them might be interesting for further study to be developed as novel antibacterial agents.

SUBMITTER: Shi XS 

PROVIDER: S-EPMC7924333 | biostudies-literature | 2021 Feb

REPOSITORIES: biostudies-literature

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Isolation and Characterization of Antibacterial Carotane Sesquiterpenes from <i>Artemisia argyi</i> Associated Endophytic <i>Trichoderma virens</i> QA-8.

Shi Xiao-Shan XS   Song Yin-Ping YP   Meng Ling-Hong LH   Yang Sui-Qun SQ   Wang Dun-Jia DJ   Zhou Xing-Wang XW   Ji Nai-Yun NY   Wang Bin-Gui BG   Li Xiao-Ming XM  

Antibiotics (Basel, Switzerland) 20210220 2


Carotane sesquiterpenes are commonly found in plants but are infrequently reported in the fungal kingdom. Chemical investigation of <i>Trichoderma virens</i> QA-8, an endophytic fungus associated with the inner root tissue of the grown medicinal herb <i>Artemisia argyi</i> H. Lév. and Vaniot, resulted in the isolation and characterization of five new carotane sesquiterpenes trichocarotins I-M (<b>1</b>-<b>5</b>), which have diverse substitution patterns, and seven known related analogues (<b>6</  ...[more]

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