Ontology highlight
ABSTRACT:
SUBMITTER: Tardelli M
PROVIDER: S-EPMC7924608 | biostudies-literature | 2021 Feb
REPOSITORIES: biostudies-literature
Tardelli Matteo M Bruschi Francesca V FV Fuchs Claudia D CD Claudel Thierry T Auer Nicole N Kunczer Victoria V Ronda Onne A H O OAHO Verkade Henkjan J HJ Stojakovic Tatjana T Scharnagl Hubert H Trauner Michael M
International journal of molecular sciences 20210220 4
Altered lipid metabolic pathways including hydrolysis of triglycerides are key players in the pathogenesis of nonalcoholic fatty liver disease (NAFLD). Whether adiponutrin (patatin-like phospholipase domain containing protein-3-PNPLA3) and monoacylglycerol lipase (MGL) synergistically contribute to disease progression remains unclear. We generated double knockout (<i>DKO</i>) mice lacking both <i>Mgl</i> and <i>Pnpla3</i>; <i>DKO</i> mice were compared to <i>Mgl<sup>-/-</sup></i> after a challen ...[more]