Ontology highlight
ABSTRACT:
SUBMITTER: Issah Y
PROVIDER: S-EPMC7924938 | biostudies-literature | 2021 Mar
REPOSITORIES: biostudies-literature
Issah Yasmine Y Naik Amruta A Tang Soon Y SY Forrest Kaitlyn K Brooks Thomas G TG Lahens Nicholas N Theken Katherine N KN Mermigos Mara M Sehgal Amita A Worthen George S GS FitzGerald Garret A GA Sengupta Shaon S
eLife 20210302
Adverse early-life exposures have a lasting negative impact on health. Neonatal hyperoxia that is a risk factor for bronchopulmonary dysplasia confers susceptibility to influenza A virus (IAV) infection later in life. Given our previous findings that the circadian clock protects against IAV, we asked if the long-term impact of neonatal hyperoxia vis-à-vis IAV infection includes circadian disruption. Here, we show that neonatal hyperoxia abolishes the clock-mediated time of day protection from IA ...[more]