Meta-analysis of neural systems underlying placebo analgesia from individual participant fMRI data.
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ABSTRACT:
SUBMITTER: Zunhammer M
PROVIDER: S-EPMC7925520 | biostudies-literature | 2021 Mar
REPOSITORIES: biostudies-literature
Publications
Meta-analysis of neural systems underlying placebo analgesia from individual participant fMRI data.
Zunhammer Matthias M Spisák Tamás T Wager Tor D TD Bingel Ulrike U
Nature communications 20210302 1
The brain systems underlying placebo analgesia are insufficiently understood. Here we performed a systematic, participant-level meta-analysis of experimental functional neuroimaging studies of evoked pain under stimulus-intensity-matched placebo and control conditions, encompassing 603 healthy participants from 20 (out of 28 eligible) studies. We find that placebo vs. control treatments induce small, widespread reductions in pain-related activity, particularly in regions belonging to ventral att ...[more]
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