Iron Deficiency in Pulmonary Arterial Hypertension: A Deep Dive into the Mechanisms.
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ABSTRACT:
SUBMITTER: Quatredeniers M
PROVIDER: S-EPMC7926484 | biostudies-literature | 2021 Feb
REPOSITORIES: biostudies-literature
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Iron Deficiency in Pulmonary Arterial Hypertension: A Deep Dive into the Mechanisms.
Quatredeniers Marceau M Mendes-Ferreira Pedro P Santos-Ribeiro Diana D Nakhleh Morad K MK Ghigna Maria-Rosa MR Cohen-Kaminsky Sylvia S Perros Frédéric F
Cells 20210223 2
Pulmonary arterial hypertension (PAH) is a severe cardiovascular disease that is caused by the progressive occlusion of the distal pulmonary arteries, eventually leading to right heart failure and death. Almost 40% of patients with PAH are iron deficient. Although widely studied, the mechanisms linking between PAH and iron deficiency remain unclear. Here we review the mechanisms regulating iron homeostasis and the preclinical and clinical data available on iron deficiency in PAH. Then we discuss ...[more]
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