Ontology highlight
ABSTRACT:
SUBMITTER: Simoni L
PROVIDER: S-EPMC7927756 | biostudies-literature | 2020 Nov
REPOSITORIES: biostudies-literature
Simoni Léa L Presumey Jessy J van der Poel Cees E CE Castrillon Carlos C Chang Sarah E SE Utz Paul J PJ Carroll Michael C MC
Cell reports 20201101 5
Systemic lupus erythematosus (SLE) is a severe autoimmune disease mediated by pathogenic autoantibodies. While complement protein C4 is associated with SLE, its isoforms (C4A and C4B) are not equal in their impact. Despite being 99% homologous, genetic studies identified C4A as more protective than C4B. By generating gene-edited mouse strains expressing either human C4A or C4B and crossing these with the 564lgi lupus strain, we show that, overall, C4A-like 564Igi mice develop less humoral autoim ...[more]