Dataset Information

Fever as a predictor of adverse outcomes in COVID-19.

ABSTRACT:

Background/introduction

There are little data on outcomes of COVID-19 patients with the presence of fever compared to the presence of symptoms.

Aim

We examined the associations between symptomology, presence of fever and outcomes of a COVID-19 cohort.

Design and methods

Between 23 January and 30 April 2020, 554 COVID-19 patients were admitted to a tertiary hospital in Singapore. They were allocated into four groups based on symptomology and fever-Group 1: asymptomatic and afebrile, Group 2: symptomatic but afebrile, Group 3: febrile but asymptomatic and Group 4: symptomatic and febrile. The primary outcomes were intensive care unit (ICU) admissions and mortality. The composite end-point included ICU admissions, mortality or any COVID-19 related end-organ involvement.

Results

There were differences in ferritin (P=0.003), C-reactive protein (CRP) levels (P<0.001) and lymphopenia (P=0.033) across all groups, with the most favourable biochemical profile in Group 1, and the least in Group 4. Symptomatic groups (Groups 2 and 4) had higher ICU admissions (1.9% and 6.0%, respectively, P=0.003) than asymptomatic groups (Groups 1 and 3). Composite end-point was highest in Group 4 (24.0%), followed by Group 3 (8.6%), Group 2 (4.8%) and Group 1 (2.4%) (P<0.001). The presence of fever (OR 4.096, 95% CI 1.737-9.656, P=0.001) was associated with the composite end-point after adjusting for age, pulse rate, comorbidities, lymphocyte, ferritin and CRP. Presence of symptoms was not associated with the composite end-point.

Discussion/conclusion

In this COVID-19 cohort, presence of fever was a predictor of adverse outcomes. This has implications on the management of febrile but asymptomatic COVID-19 patients.

SUBMITTER: Chew NW

PROVIDER: S-EPMC7928573 | biostudies-literature | 2021 Dec

REPOSITORIES: biostudies-literature

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Publications

Fever as a predictor of adverse outcomes in COVID-19.

Chew N W NW Ngiam J N JN Tham S M SM Lim Z Y ZY Li T Y W TYW Cen S S Yap E S ES Tambyah P A PA Santosa A A Cross G B GB Sia C-H CH

QJM : monthly journal of the Association of Physicians 20211201 10

<h4>Background/introduction</h4>There are little data on outcomes of COVID-19 patients with the presence of fever compared to the presence of symptoms.<h4>Aim</h4>We examined the associations between symptomology, presence of fever and outcomes of a COVID-19 cohort.<h4>Design and methods</h4>Between 23 January and 30 April 2020, 554 COVID-19 patients were admitted to a tertiary hospital in Singapore. They were allocated into four groups based on symptomology and fever-Group 1: asymptomatic and a ...[more]

PMID: 33533902

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Dataset Information

Fever as a predictor of adverse outcomes in COVID-19.

Background/introduction

Aim

Design and methods

Results

Discussion/conclusion

Publications

Fever as a predictor of adverse outcomes in COVID-19.

Similar Datasets

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