Ontology highlight
ABSTRACT:
SUBMITTER: Brown M
PROVIDER: S-EPMC7928940 | biostudies-literature | 2021 Jan
REPOSITORIES: biostudies-literature
Brown Michael M Aljarah Mohammed M Asiki Hannah H Leung Leo M H LMH Smithen Deborah A DA Miller Natalie N Nemeth Gabor G Davies Lawrence L Niculescu-Duvaz Dan D Zambon Alfonso A Springer Caroline C
Organic process research & development 20201015 1
The scale-up of a chiral bicyclic homopiperazine of pharmaceutical interest was investigated. The outcome and safety profile of a key batch ring-expansion step via Schmidt rearrangement was improved using continuous-flow chemistry. The selectivity of nitrogen insertion for the ring expansion was improved via an alternative photochemical oxaziridine rearrangement under mild conditions, which when converted to continuous-flow in a simple and efficient flow reactor allowed the first photochemical s ...[more]