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Development and Scale-up of the Rapid Synthesis of Triphenyl Phosphites in Continuous Flow.

ABSTRACT: A novel method for the synthesis of triphenyl phosphite and its derivatives has been developed in continuous flow. With a total residence time of 20 s, the target product was prepared in a microreactor, and the reaction time was significantly shortened compared with standard single batch reaction conditions. In addition, the reaction of various substrates gave the corresponding products in good to excellent yields under optimized conditions. The reactants could be employed in a stoichiometric ratio, making the reaction more efficient, economical, and environmentally friendly. In addition, scale-up apparatus was designed and assembled, and the kilogram-scale production (up to 18.4 kg/h) of tris(2,4-di-tert-butylphenyl) phosphite was achieved in 88% yield.

SUBMITTER: Mao M

PROVIDER: S-EPMC7191834 | biostudies-literature | 2020 Apr

REPOSITORIES: biostudies-literature

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Development and Scale-up of the Rapid Synthesis of Triphenyl Phosphites in Continuous Flow.

Mao Mengmei M Zhang Le L Yao Hanlin H Wan Li L Xin Zhong Z

ACS omega 20200417 16

A novel method for the synthesis of triphenyl phosphite and its derivatives has been developed in continuous flow. With a total residence time of 20 s, the target product was prepared in a microreactor, and the reaction time was significantly shortened compared with standard single batch reaction conditions. In addition, the reaction of various substrates gave the corresponding products in good to excellent yields under optimized conditions. The reactants could be employed in a stoichiometric ra ...[more]

PMID: 32363302

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