MRGBP, a member of the NuA4 complex, inhibits DNA double-strand break repair.
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ABSTRACT:
SUBMITTER: Rivero S
PROVIDER: S-EPMC7931222 | biostudies-literature | 2021 Mar
REPOSITORIES: biostudies-literature
Publications
MRGBP, a member of the NuA4 complex, inhibits DNA double-strand break repair.
Rivero Sabrina S Rodríguez-Real Guillermo G Marín Inés I Huertas Pablo P
FEBS open bio 20210220 3
The repair of DNA breaks takes place in the context of chromatin and thus involves the activity of chromatin remodelers. The nucleosome acetyltransferase of H4 (NuA4) remodeler complex enables DNA break repair by relaxing flanking chromatin. Here, we show that MRG domain binding protein (MRGBP), a member of this complex, acts as a general inhibitor of DNA double-strand break repair. Upon its downregulation, repair is generally increased. This is particularly evident for the stimulation of early ...[more]
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