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Effect of Lauric Acid on the Stability of A?42 Oligomers.


ABSTRACT: While Alzheimer's disease is correlated with the presence of A? fibrils in patient brains, the more likely agents are their precursors, soluble oligomers that may form pores or otherwise distort cell membranes. Using all-atom molecular dynamics simulation, we study how the presence of fatty acids such as lauric acid changes the stability of pore-forming oligomers built from three-stranded A?42 chains. Such a change would alter the distribution of amyloids in the fatty acid-rich brain environment and therefore could explain the lower polymorphism observed in A? fibrils derived from brains of patients with Alzheimer's disease. We find that lauric acid stabilizes both ring-like and barrel-shaped models, with the effect being stronger for barrel-like models than for ring-like oligomers.

SUBMITTER: Khatua P 

PROVIDER: S-EPMC7931375 | biostudies-literature | 2021 Mar

REPOSITORIES: biostudies-literature

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Effect of Lauric Acid on the Stability of Aβ<sub>42</sub> Oligomers.

Khatua Prabir P   Jana Asis K AK   Hansmann Ulrich H E UHE  

ACS omega 20210217 8


While Alzheimer's disease is correlated with the presence of Aβ fibrils in patient brains, the more likely agents are their precursors, soluble oligomers that may form pores or otherwise distort cell membranes. Using all-atom molecular dynamics simulation, we study how the presence of fatty acids such as lauric acid changes the stability of pore-forming oligomers built from three-stranded Aβ<sub>42</sub> chains. Such a change would alter the distribution of amyloids in the fatty acid-rich brain  ...[more]

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