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Cu(II)-Containing Metal-Organic Framework with 1D Hexagonal Channels for Cyanosilylation Reaction and Anticancer Activity on Osteosarcoma Cells.


ABSTRACT: A novel metal-organic framework (MOF) has been produced via Cu(NO3)2·6H2O reaction with 3-(1H-tetrazol-5-yl)pyridine (HL) in water, and its chemical formula is {[(Cu(L)2(H2O)2](H2O)8) n } (1). Due to its high density of coordinately unsaturated sites along with large one-dimensional (1D) hexagonal channels, the activated complex 1 (1a) was explored as the solvent-free heterogeneous catalyst for cyanosilylation under mind conditions. The inhibitory function of compound 1a against the survival rate of OS-732 osteosarcoma cells was evaluated via Cell Counting Kit-8 (CCK-8) detection kit. Furthermore, the Annexin V-FITC/PI detection kit and the active oxygen (ROS) detection kit was carried out to determine the cell apoptosis levels and the ROS accumulation in OS-732 osteosarcoma cells after treatment by compound 1a.

SUBMITTER: Luo J 

PROVIDER: S-EPMC7931417 | biostudies-literature | 2021 Mar

REPOSITORIES: biostudies-literature

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Cu(II)-Containing Metal-Organic Framework with 1D Hexagonal Channels for Cyanosilylation Reaction and Anticancer Activity on Osteosarcoma Cells.

Luo Jian J   Ying Lv-Fang LF   Zhang Feng F   Zhou Ze Z   Zhang Yan-Guo YG  

ACS omega 20210218 8


A novel metal-organic framework (MOF) has been produced via Cu(NO<sub>3</sub>)<sub>2</sub>·6H<sub>2</sub>O reaction with 3-(1<i>H</i>-tetrazol-5-yl)pyridine (HL) in water, and its chemical formula is {[(Cu(L)<sub>2</sub>(H<sub>2</sub>O)<sub>2</sub>](H<sub>2</sub>O)<sub>8</sub>) <i><sub>n</sub></i> } (<b>1</b>). Due to its high density of coordinately unsaturated sites along with large one-dimensional (1D) hexagonal channels, the activated complex <b>1</b> (<b>1a</b>) was explored as the solvent-  ...[more]

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