Developmental hourglass and heterochronic shifts in fin and limb development.
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ABSTRACT:
SUBMITTER: Onimaru K
PROVIDER: S-EPMC7932699 | biostudies-literature | 2021 Feb
REPOSITORIES: biostudies-literature
Publications
Developmental hourglass and heterochronic shifts in fin and limb development.
Onimaru Koh K Tatsumi Kaori K Tanegashima Chiharu C Kadota Mitsutaka M Nishimura Osamu O Kuraku Shigehiro S
eLife 20210209
How genetic changes are linked to morphological novelties and developmental constraints remains elusive. Here, we investigate genetic apparatuses that distinguish fish fins from tetrapod limbs by analyzing transcriptomes and open-chromatin regions (OCRs). Specifically, we compared mouse forelimb buds with the pectoral fin buds of an elasmobranch, the brown-banded bamboo shark (<i>Chiloscyllium punctatum</i>). A transcriptomic comparison with an accurate orthology map revealed both a mass heteroc ...[more]
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