Functional analysis of limb enhancers in the developing fin.
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ABSTRACT:
SUBMITTER: Booker BM
PROVIDER: S-EPMC3869458 | biostudies-literature | 2013 Nov
REPOSITORIES: biostudies-literature
Publications
Functional analysis of limb enhancers in the developing fin.
Booker Betty M BM Murphy Karl K KK Ahituv Nadav N
Development genes and evolution 20130926 6
Despite diverging ∼365 million years ago, tetrapod limbs and pectoral fins express similar genes that could be regulated by shared regulatory elements. In this study, we set out to analyze the ability of enhancers to maintain tissue specificity in these two divergent structures. We tested 22 human sequences that were previously reported as mouse limb enhancers for their enhancer activity in zebrafish (Danio rerio). Using a zebrafish enhancer assay, we found that 10/22 (45 %) were positive for pe ...[more]
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