Ontology highlight
ABSTRACT:
SUBMITTER: Dela Cruz C
PROVIDER: S-EPMC7933197 | biostudies-literature | 2020
REPOSITORIES: biostudies-literature
Dela Cruz Cynthia C Horton Cassandra A CA Sanders Kelsey N KN Andersen Nathan D ND Tsai Pei-San PS
Frontiers in endocrinology 20210219
In humans and mice, inactivating mutations in fibroblast growth factor receptor 1 (<i>Fgfr1</i>) lead to gonadotropin-releasing hormone (GnRH) deficiency and a host of downstream reproductive disorders. It was unclear if Fgfr1 signaling directly upon GnRH neurons critically drove the establishment of a functional GnRH system. To answer this question, we generated a mouse model with a conditional deletion of <i>Fgfr1</i> in GnRH neurons using the Cre/loxP approach. These mice, called <i>Fgfr1cKO< ...[more]