Ontology highlight
ABSTRACT:
SUBMITTER: Mok TH
PROVIDER: S-EPMC7933407 | biostudies-literature | 2021 Mar
REPOSITORIES: biostudies-literature
Mok Tze How TH Nihat Akin A Luk Connie C Sequeira Danielle D Batchelor Mark M Mead Simon S Collinge John J Jackson Graham S GS
Scientific reports 20210304 1
The cerebrospinal fluid (CSF) real-time quaking-induced conversion assay (RT-QuIC) is an ultrasensitive prion amyloid seeding assay for diagnosis of sporadic Creutzfeldt-Jakob disease (CJD) but several prion strains remain unexplored or resistant to conversion with commonly used recombinant prion protein (rPrP) substrates. Here, bank vole (BV) rPrP was used to study seeding by a wide range of archived post-mortem human CSF samples from cases of sporadic, acquired and various inherited prion dise ...[more]