Ontology highlight
ABSTRACT:
SUBMITTER: Huang X
PROVIDER: S-EPMC7933962 | biostudies-literature | 2021 Mar
REPOSITORIES: biostudies-literature
Huang Xiaoli X Chao Ruihua R Zhang Yanyang Y Wang Pengxiang P Gong Xueping X Liang Dongli D Wang Yuan Y
Journal of cellular and molecular medicine 20210126 5
The exact molecular mechanism underlying erythroblast enucleation has been a fundamental biological question for decades. In this study, we found that miR-144/451 critically regulated erythroid differentiation and enucleation. We further identified CAP1, a G-actin-binding protein, as a direct target of miR-144/451 in these processes. During terminal erythropoiesis, CAP1 expression declines along with gradually increased miR-144/451 levels. Enforced CAP1 up-regulation inhibits the formation of co ...[more]