Dataset Information

Electromagnetic Brain Source Imaging by Means of a Robust Minimum Variance Beamformer.

ABSTRACT:

Objective

Adaptive beamformer methods that have been extensively used for functional brain imaging using EEG/MEG (magnetoencephalography) signals are sensitive to model mismatches. We propose a robust minimum variance beamformer (RMVB) technique, which explicitly incorporates the uncertainty of the lead field matrix into the estimation of spatial-filter weights that are subsequently used to perform the imaging.

Methods

The uncertainty of the lead field is modeled by ellipsoids in the RMVB method; these hyperellipsoids (ellipsoids in higher dimensions) define regions of uncertainty for a given nominal lead field vector. These ellipsoids are estimated empirically by sampling lead field vectors surrounding each point of the source space, or more generally by building several forward models for the source space. Once these uncertainty regions (ellipsoids) are estimated, they are used to perform the source-imaging task. Computer simulations are conducted to evaluate the performance of the proposed RMVB technique.

Results

Our results show that robust beamformers can outperform conventional beamformers in terms of localization error, recovering source dynamics, and estimation of the underlying source extents when uncertainty in the lead field matrix is properly determined and modeled.

Conclusion

The RMVB can be substituted for conventional beamformers, especially in applications where source imaging is performed off-line, and computational speed and complexity are not of major concern.

Significance

A high-quality source imaging can be utilized in various applications, such as determining the epileptogenic zone in medically intractable epilepsy patients or estimating the time course of activity, which is a required step for computing the functional connectivity of brain networks.

SUBMITTER: Hossein Hosseini SA

PROVIDER: S-EPMC7934089 | biostudies-literature | 2018 Oct

REPOSITORIES: biostudies-literature

ACCESS DATA

Publications

Electromagnetic Brain Source Imaging by Means of a Robust Minimum Variance Beamformer.

Hossein Hosseini Seyed Amir SA Sohrabpour Abbas A Akcakaya Mehmet M He Bin B

IEEE transactions on bio-medical engineering 20180724 10

<h4>Objective</h4>Adaptive beamformer methods that have been extensively used for functional brain imaging using EEG/MEG (magnetoencephalography) signals are sensitive to model mismatches. We propose a robust minimum variance beamformer (RMVB) technique, which explicitly incorporates the uncertainty of the lead field matrix into the estimation of spatial-filter weights that are subsequently used to perform the imaging.<h4>Methods</h4>The uncertainty of the lead field is modeled by ellipsoids in ...[more]

PMID: 30047869

Similar Datasets

Project description:Beamformers are applied for estimating spatiotemporal characteristics of neuronal sources underlying measured MEG/EEG signals. Several MEG analysis toolboxes include an implementation of a linearly constrained minimum-variance (LCMV) beamformer. However, differences in implementations and in their results complicate the selection and application of beamformers and may hinder their wider adoption in research and clinical use. Additionally, combinations of different MEG sensor types (such as magnetometers and planar gradiometers) and application of preprocessing methods for interference suppression, such as signal space separation (SSS), can affect the results in different ways for different implementations. So far, a systematic evaluation of the different implementations has not been performed. Here, we compared the localization performance of the LCMV beamformer pipelines in four widely used open-source toolboxes (MNE-Python, FieldTrip, DAiSS (SPM12), and Brainstorm) using datasets both with and without SSS interference suppression. We analyzed MEG data that were i) simulated, ii) recorded from a static and moving phantom, and iii) recorded from a healthy volunteer receiving auditory, visual, and somatosensory stimulation. We also investigated the effects of SSS and the combination of the magnetometer and gradiometer signals. We quantified how localization error and point-spread volume vary with the signal-to-noise ratio (SNR) in all four toolboxes. When applied carefully to MEG data with a typical SNR (3-15 dB), all four toolboxes localized the sources reliably; however, they differed in their sensitivity to preprocessing parameters. As expected, localizations were highly unreliable at very low SNR, but we found high localization error also at very high SNRs for the first three toolboxes while Brainstorm showed greater robustness but with lower spatial resolution. We also found that the SNR improvement offered by SSS led to more accurate localization.

Project description:Estimating extended brain sources using EEG/MEG source imaging techniques is challenging. EEG and MEG have excellent temporal resolution at millisecond scale but their spatial resolution is limited due to the volume conduction effect. We have exploited sparse signal processing techniques in this study to impose sparsity on the underlying source and its transformation in other domains (mathematical domains, like spatial gradient). Using an iterative reweighting strategy to penalize locations that are less likely to contain any source, it is shown that the proposed iteratively reweighted edge sparsity minimization (IRES) strategy can provide reasonable information regarding the location and extent of the underlying sources. This approach is unique in the sense that it estimates extended sources without the need of subjectively thresholding the solution. The performance of IRES was evaluated in a series of computer simulations. Different parameters such as source location and signal-to-noise ratio were varied and the estimated results were compared to the targets using metrics such as localization error (LE), area under curve (AUC) and overlap between the estimated and simulated sources. It is shown that IRES provides extended solutions which not only localize the source but also provide estimation for the source extent. The performance of IRES was further tested in epileptic patients undergoing intracranial EEG (iEEG) recording for pre-surgical evaluation. IRES was applied to scalp EEGs during interictal spikes, and results were compared with iEEG and surgical resection outcome in the patients. The pilot clinical study results are promising and demonstrate a good concordance between noninvasive IRES source estimation with iEEG and surgical resection outcomes in the same patients. The proposed algorithm, i.e. IRES, estimates extended source solutions from scalp electromagnetic signals which provide relatively accurate information about the location and extent of the underlying source.

Project description:ObjectiveThe goal of this study is to investigate the performance, merits and limitations of source imaging using intracranial EEG (iEEG) recordings and to compare its accuracy to the results of EEG source imaging. Accuracy in this study, is measured both by determining the location and inter-nodal connectivity of underlying brain networks.MethodsSystematic computer simulation studies are conducted to evaluate iEEG-based source imaging vs. EEG-based source imaging, and source imaging using both EEG and iEEG. To test the source imaging models, networks of inter-connected nodes (in terms of activity) are simulated. The location of the network nodes is randomly selected within a realistic geometry head model and a connectivity link is created among these nodes based on a multi-variate auto-regressive (MVAR) model. Then the forward problem is solved to calculate the potentials at the electrodes and noise (white and correlated) is added to these simulated potentials to simulate realistic measurements. Subsequently, the inverse problem is solved and an algorithm based on principle component analysis is performed on the estimated source activities to determine the location of the simulated network nodes. The activity of these nodes (over time), is then extracted, and used to estimate the connectivity links among the mentioned nodes using Granger causality analysis.ResultsSource imaging based on iEEG recordings may or may not improve the accuracy in localization, depending on the number and location of active nodes relative to iEEG electrodes and to other nodes within the network. However, our simulation results suggest that combining EEG and iEEG modalities (simultaneous scalp and intracranial recordings) can improve the imaging accuracy significantly.ConclusionsWhile iEEG source imaging is useful in estimating the exact location of sources near the iEEG electrodes, combining EEG and iEEG recordings can achieve a more accurate imaging due to the high spatial coverage of the scalp electrodes and the added near field information provided by the iEEG electrodes.SignificanceThe present results suggest the feasibility of localizing brain electrical sources from iEEG recordings and improving EEG source localization using simultaneous EEG and iEEG recordings to cover the whole brain. The hybrid EEG and iEEG source imaging can assist the clinicians when unequivocal decisions about determining the epileptogenic zone cannot be reached using a single modality.

Project description:ObjectiveCombined source-imaging techniques and directional connectivity analysis can provide useful information about the underlying brain networks in a noninvasive fashion. Source-imaging techniques have been used successfully to either determine the source of activity or to extract source time-courses for Granger causality analysis, previously. In this work, we utilize source-imaging algorithms to both find the network nodes [regions of interest (ROI)] and then extract the activation time series for further Granger causality analysis. The aim of this work is to find network nodes objectively from noninvasive electromagnetic signals, extract activation time-courses, and apply Granger analysis on the extracted series to study brain networks under realistic conditions.MethodsSource-imaging methods are used to identify network nodes and extract time-courses and then Granger causality analysis is applied to delineate the directional functional connectivity of underlying brain networks. Computer simulations studies where the underlying network (nodes and connectivity pattern) is known were performed; additionally, this approach has been evaluated in partial epilepsy patients to study epilepsy networks from interictal and ictal signals recorded by EEG and/or Magnetoencephalography (MEG).ResultsLocalization errors of network nodes are less than 5 mm and normalized connectivity errors of ∼20% in estimating underlying brain networks in simulation studies. Additionally, two focal epilepsy patients were studied and the identified nodes driving the epileptic network were concordant with clinical findings from intracranial recordings or surgical resection.ConclusionOur study indicates that combined source-imaging algorithms with Granger causality analysis can identify underlying networks precisely (both in terms of network nodes location and internodal connectivity).SignificanceThe combined source imaging and Granger analysis technique is an effective tool for studying normal or pathological brain conditions.

Dataset Information

Electromagnetic Brain Source Imaging by Means of a Robust Minimum Variance Beamformer.

Objective

Methods

Results

Conclusion

Significance

Publications

Electromagnetic Brain Source Imaging by Means of a Robust Minimum Variance Beamformer.

Similar Datasets

OmicsDI is part of the ELIXIR infrastructure

Tweets