Ontology highlight
ABSTRACT:
SUBMITTER: Nozuma S
PROVIDER: S-EPMC7934934 | biostudies-literature | 2021 Feb
REPOSITORIES: biostudies-literature
Nozuma Satoshi S Enose-Akahata Yoshimi Y Johnson Kory R KR Monaco Maria Chiara MC Ngouth Nyater N Elkahloun Abdel A Ohayon Joan J Zhu Jun J Jacobson Steven S
JCI insight 20210222 4
In this study, we examined and characterized disease-specific TCR signatures in cerebrospinal fluid (CSF) of patients with HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP). TCR β libraries using unique molecular identifier-based methodologies were sequenced in paired peripheral blood mononuclear cells (PBMCs) and CSF cells from HAM/TSP patients and normal healthy donors (NDs). The sequence analysis demonstrated that TCR β repertoires in CSF of HAM/TSP patients were highly expa ...[more]