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Clinical evidence of the role of Methanobrevibacter smithii in severe acute malnutrition.

ABSTRACT: Gut microbial dysbiosis has been shown to be an instrumental factor in severe acute malnutrition (SAM) and particularly, the absence of Methanobrevibacter smithii, a key player in energy harvest. Nevertheless, it remains unknown whether this absence reflects an immaturity or a loss of the microbiota. In order to assess that, we performed a case-control study in Mali using a propensity score weighting approach. The presence of M. smithii was tested using quantitative PCR on faeces collected from SAM children at inclusion and at discharge when possible or at day 15 for controls. M. smithii was highly significantly associated with the absence of SAM, detected in 40.9% controls but only in 4.2% cases (p?

SUBMITTER: Camara A

PROVIDER: S-EPMC7940396 | biostudies-literature | 2021 Mar

REPOSITORIES: biostudies-literature

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Clinical evidence of the role of Methanobrevibacter smithii in severe acute malnutrition.

Camara Aminata A Konate Salimata S Tidjani Alou Maryam M Kodio Aly A Togo Amadou Hamidou AH Cortaredona Sebastien S Henrissat Bernard B Thera Mahamadou Ali MA Doumbo Ogobara K OK Raoult Didier D Million Matthieu M

Scientific reports 20210308 1

Gut microbial dysbiosis has been shown to be an instrumental factor in severe acute malnutrition (SAM) and particularly, the absence of Methanobrevibacter smithii, a key player in energy harvest. Nevertheless, it remains unknown whether this absence reflects an immaturity or a loss of the microbiota. In order to assess that, we performed a case-control study in Mali using a propensity score weighting approach. The presence of M. smithii was tested using quantitative PCR on faeces collected from ...[more]

PMID: 33686095

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Methanobrevibacter smithii expression profiling

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Structure modeling and inhibitor prediction ofNADP oxidoreductase enzyme from Methanobrevibacter smithii.

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