Ontology highlight
ABSTRACT:
SUBMITTER: Ponedal A
PROVIDER: S-EPMC7946158 | biostudies-literature | 2020 Dec
REPOSITORIES: biostudies-literature
Ponedal Adam A Zhu Shengshuang S Sprangers Anthony J AJ Wang Xiao-Qi XQ Yeo David C DC Lio Daniel C S DCS Zheng Mengjia M Capek Matthew M Narayan Suguna P SP Meckes Brian B Paller Amy S AS Xu Chenjie C Mirkin Chad A CA
ACS applied bio materials 20201113 12
Abnormal scarring is a consequence of dysregulation in the wound healing process, with limited options for effective and noninvasive therapies. Given the ability of spherical nucleic acids (SNAs) to penetrate skin and regulate gene expression within, we investigated whether gold-core SNAs (AuSNAs) and liposome-core SNAs (LSNAs) bearing antisense oligonucleotides targeting transforming growth factor beta 1 (TGF-<i>β</i>1) can function as a topical therapy for scarring. Importantly, both SNA const ...[more]