Ontology highlight
ABSTRACT:
SUBMITTER: Wang Y
PROVIDER: S-EPMC7946420 | biostudies-literature | 2021 Mar
REPOSITORIES: biostudies-literature
Wang Yawei Y Toyoshima Osamu O Kunimatsu Jun J Yamada Hiroshi H Matsumoto Masayuki M
eLife 20210310
Animal behavior is regulated based on the values of future rewards. The phasic activity of midbrain dopamine neurons signals these values. Because reward values often change over time, even on a subsecond-by-subsecond basis, appropriate behavioral regulation requires continuous value monitoring. However, the phasic dopamine activity, which is sporadic and has a short duration, likely fails continuous monitoring. Here, we demonstrate a tonic firing mode of dopamine neurons that effectively tracks ...[more]