Ontology highlight
ABSTRACT:
SUBMITTER: Agrahari G
PROVIDER: S-EPMC7947887 | biostudies-literature | 2021
REPOSITORIES: biostudies-literature
Agrahari Gaurav G Sah Shyam Kishor SK Bang Chul Hwan CH Kim Yeong Ho YH Kim Tae-Yoon TY
Frontiers in immunology 20210225
Superoxide dismutase 3 (SOD3), a well-known antioxidant has been shown to possess immunomodulatory properties through inhibition of T cell differentiation. However, the underlying inhibitory mechanism of SOD3 on T cell differentiation is not well understood. In this study, we investigated the effect of SOD3 on anti-CD3/CD28- or phorbol myristate acetate (PMA) and ionomycin (ION)-mediated activation of mouse naive CD4<sup>+</sup> T cells. Our data showed that SOD3 suppressed the expression of act ...[more]