Editing GWAS: experimental approaches to dissect and exploit disease-associated genetic variation.
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ABSTRACT:
SUBMITTER: Rao S
PROVIDER: S-EPMC7948363 | biostudies-literature | 2021 Mar
REPOSITORIES: biostudies-literature
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Editing GWAS: experimental approaches to dissect and exploit disease-associated genetic variation.
Rao Shuquan S Yao Yao Y Bauer Daniel E DE
Genome medicine 20210310 1
Genome-wide association studies (GWAS) have uncovered thousands of genetic variants that influence risk for human diseases and traits. Yet understanding the mechanisms by which these genetic variants, mainly noncoding, have an impact on associated diseases and traits remains a significant hurdle. In this review, we discuss emerging experimental approaches that are being applied for functional studies of causal variants and translational advances from GWAS findings to disease prevention and treat ...[more]
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