The use of extracorporeal CO₂ removal in acute respiratory failure.

ABSTRACT:

Background

Chronic obstructive pulmonary disease (COPD) exacerbation and protective mechanical ventilation of acute respiratory distress syndrome (ARDS) patients induce hypercapnic respiratory acidosis.

Main text

Extracorporeal carbon dioxide removal (ECCO₂R) aims to eliminate blood CO₂ to fight against the adverse effects of hypercapnia and related acidosis. Hypercapnia has deleterious extrapulmonary consequences, particularly for the brain. In addition, in the lung, hypercapnia leads to: lower pH, pulmonary vasoconstriction, increases in right ventricular afterload, acute cor pulmonale. Moreover, hypercapnic acidosis may further damage the lungs by increasing both nitric oxide production and inflammation and altering alveolar epithelial cells. During

SUBMITTER: Giraud R 

PROVIDER: S-EPMC7951130 | biostudies-literature | 2021 Mar

REPOSITORIES: biostudies-literature