Dataset Information

Muscle endurance deficits in myositis patients despite normal manual muscle testing scores.

ABSTRACT:

Introduction

It is unclear whether quantitating muscle endurance adds nonredundant information useful for the care of patients with muscular disease.

Methods

Records were retrospectively reviewed for all Johns Hopkins Myositis Center patients with a muscle endurance assessment (n?=?128, 226 patient-visits). Muscle endurance and strength were quantitated with the Myositis Functional Index-2 (FI2) and manual muscle testing (MMT), respectively.

Results

Composite FI2 muscle endurance scores were comparable in inclusion body myositis (n?=?58), dermatomyositis (n?=?31), and polymyositis (n?=?39). Overall, muscle endurance correlated with and evolved similarly to strength, inversely to serum creatine kinase. However, in patients with normal or near-normal strength (mean MMT?>?9.75/10), muscle endurance was typically abnormal and highly variable (mean FI2, 5.6/10; interquartile range, 3.3-7.8/10).

Discussion

Muscle endurance testing may identify muscle impairment inadequately described by MMT, particularly in patients with high MMT scores. Muscle Nerve 59:70-75, 2019.

SUBMITTER: Amici DR

PROVIDER: S-EPMC7951326 | biostudies-literature | 2019 Jan

REPOSITORIES: biostudies-literature

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Publications

Muscle endurance deficits in myositis patients despite normal manual muscle testing scores.

Amici David R DR Pinal-Fernandez Iago I Pagkatipunan Ruben R Mears Albert A de Lorenzo Rebecca R Tiniakou Eleni E Albayda Jemima J Paik Julie J JJ Lloyd Thomas E TE Christopher-Stine Lisa L Mammen Andrew L AL Chung Tae T

Muscle & nerve 20181218 1

<h4>Introduction</h4>It is unclear whether quantitating muscle endurance adds nonredundant information useful for the care of patients with muscular disease.<h4>Methods</h4>Records were retrospectively reviewed for all Johns Hopkins Myositis Center patients with a muscle endurance assessment (n = 128, 226 patient-visits). Muscle endurance and strength were quantitated with the Myositis Functional Index-2 (FI2) and manual muscle testing (MMT), respectively.<h4>Results</h4>Composite FI2 muscle end ...[more]

PMID: 30028529

Similar Datasets

Project description:ObjectiveTo identify changes in skeletal muscle microRNA expression after endurance exercise and associate the identified microRNAs with mRNA and protein expression to disease-specific pathways in polymyositis (PM) and dermatomyositis (DM) patients.MethodsFollowing a parallel clinical trial design, patients with probable PM or DM, exercising less than once a week, and on stable medication for at least one month were randomized into two groups at Karolinska University Hospital: a 12-week endurance exercise group (n = 12) or a non-exercised control group (n = 11). Using an Affymetrix microarray, microRNA expression was determined in paired muscle biopsies taken before and after the exercise intervention from 3 patients in each group. Ingenuity pathway analysis with a microRNA target filter was used to identify microRNA transcript targets. These targets were investigated at the mRNA (microarray) and protein (mass spectrometry) levels in patients.ResultsEndurance exercise altered 39 microRNAs. The microRNAs with increased expression were predicted to target transcripts involved in inflammatory processes, metabolism, and muscle atrophy. Further, these target transcripts had an associated decrease in mRNA expression in exercised patients. In particular, a decrease in the NF-κB regulator IKBKB was associated with an increase in its target microRNA (miR-196b). At the protein level, there was an increase in mitochondrial proteins (AK3, HIBADH), which were associated with a decrease in microRNAs that were predicted to regulate their expression.ConclusionImprovement in disease phenotype after exercise is associated with increasing microRNAs that target and downregulate immune processes at the transcript level, as well as decreasing microRNAs that target and upregulate mitochondrial content at the protein level. Therefore, microRNAs may improve disease by decreasing immune responses and increasing mitochondrial biogenesis.Trial registrationClinicalTrials.gov NCT01184625.

Dataset Information

Muscle endurance deficits in myositis patients despite normal manual muscle testing scores.

Introduction

Methods

Results

Discussion

Publications

Muscle endurance deficits in myositis patients despite normal manual muscle testing scores.

Similar Datasets

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