Ontology highlight
ABSTRACT:
SUBMITTER: Debruycker V
PROVIDER: S-EPMC7951658 | biostudies-literature | 2020 Sep
REPOSITORIES: biostudies-literature
Nature structural & molecular biology 20200727 9
Multidrug efflux pumps present a challenge to the treatment of bacterial infections, making it vitally important to understand their mechanism of action. Here, we investigate the nature of substrate binding within Lactococcus lactis LmrP, a prototypical multidrug transporter of the major facilitator superfamily. We determined the crystal structure of LmrP in a ligand-bound outward-open state and observed an embedded lipid in the binding cavity of LmrP, an observation supported by native mass spe ...[more]