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Differences between two sodium hyaluronate-based submucosal injection materials currently used in Japan based on viscosity analysis.

ABSTRACT: In Japan, two 0.4% sodium hyaluronate (HA)-based submucosal injection materials (SIMs) are currently used in endoscopic submucosal dissection (ESD): MucoUp (HA-Mc) and Ksmart (HA-Ks). HA-Mc and HA-Ks have the same concentration and are, thus, construed by most endoscopists to have no difference. Nevertheless, visual observation conveys the impression that HA-Ks have a higher viscosity than HA-Mc, suggesting that HA-Ks performs better than HA-Mc. This study aimed to examine the differences between HA-Mc and HA-Ks. HA-Ks exhibited higher viscosity due to greater weight-average molecular weight compared with HA-Mc. HA-Ks had significantly greater submucosal elevation height (SEH) than HA-Mc; the SEH of HA-Ks-80% (80% dilution of HA-Ks) was the same as that of HA-Mc. The ESD procedure time was significantly shorter with HA-Ks than with HA-Mc (15.2?±?4.1 vs. 19.5?±?5.9; P?=?0.049). The total injection volume for HA-Ks was significantly lower than that for HA-Mc (10.8?±?3.6 vs. 14.4?±?4.6; P?=?0.045). However, no significant difference in these items was observed between HA-Mc and HA-Ks-80%. HA-Mc and HA-Ks were considered to be almost the same. Nonetheless, HA-Ks exhibited higher viscosity and SIM performance than HA-Mc. HA-Ks-80% had almost the same performance as HA-Mc. Thus, understanding SIM performance and characteristics requires a focus on the viscosity of SIMs.

SUBMITTER: Hirose R

PROVIDER: S-EPMC7952736 | biostudies-literature | 2021 Mar

REPOSITORIES: biostudies-literature

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Differences between two sodium hyaluronate-based submucosal injection materials currently used in Japan based on viscosity analysis.

Hirose Ryohei R Yoshida Takuma T Naito Yuji Y Watanabe Naoto N Hashimoto Hikaru H Sugino Satoshi S Bandou Risa R Daidoji Tomo T Inoue Ken K Dohi Osamu O Yoshida Naohisa N Nakaya Takaaki T Itoh Yoshito Y

Scientific reports 20210311 1

In Japan, two 0.4% sodium hyaluronate (HA)-based submucosal injection materials (SIMs) are currently used in endoscopic submucosal dissection (ESD): MucoUp (HA-Mc) and Ksmart (HA-Ks). HA-Mc and HA-Ks have the same concentration and are, thus, construed by most endoscopists to have no difference. Nevertheless, visual observation conveys the impression that HA-Ks have a higher viscosity than HA-Mc, suggesting that HA-Ks performs better than HA-Mc. This study aimed to examine the differences betwee ...[more]

PMID: 33707637

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Project description:Background:Recent artificial tear preparations have provided 0.2% concentration of sodium hyaluronate. However, no published data exist on their potential superiority against 0.1% in alleviating dry-eye-disease symptoms in cataract extraction surgery. Methods:A total of 180 patients that underwent cataract extraction surgery were randomly divided into 2 groups according to their postoperative regime: Study group (SG) received fixed combination of tobramycin and dexamethasone (FCTD) quid for 3?weeks, and additionally 0.2% sodium hyaluronate provided in the COMOD® device quid for 6?weeks. Control group (CG) received fixed combination of tobramycin and dexamethasone (FCTD) quid for 3?weeks, and additionally 0.1% sodium hyaluronate provided in the COMOD® device quid for 6?weeks. The following indexes were evaluated at 3 postoperative checkpoints: 1) Surface discomfort index (SDI) which was derived by four direct 10-scale Likert-type questions that were addressed to the patient and pertained to: a) foreign body sensation (FBS), b) blinking discomfort (BD), c) stinging sensation (SS), d) tearing sensation (TS), 2) Tear break-up time (TBUT), 3) Schirmer's test, 4) Central corneal thickness (CCT), and 4) Central Corneal Sensitivity (CCS). Results:Both groups showed reduced CCS values at all postoperative examination points; however, SG participants had significantly better CCS (all p <?0.05). SG had better TBUT than CG at the 3rd (p =?0.03) and 6th examination points (p =?0.04). Moreover, SG had better SDI scores at the 3rd (SDI?=?9.26?±?0.55) and 6th weeks (SDI?=?9.47?±?0.48) vs. CG participants (p =?0.03 and p <?0.01, respectively). Conclusion:The increased 0.2% sodium hyaluronate concentration in the artificial tears provided in the COMOD® device seems to address dry-eye-disease symptoms better in patients who underwent phacoemulsification surgery than the 0.1% concentration. Trial registration:ClinicalTrials.gov Identifier: NCT03705949 Oct 15, 2018, retrospectively registered.

Dataset Information

Differences between two sodium hyaluronate-based submucosal injection materials currently used in Japan based on viscosity analysis.

Publications

Differences between two sodium hyaluronate-based submucosal injection materials currently used in Japan based on viscosity analysis.

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