Ontology highlight
ABSTRACT:
SUBMITTER: Versaevel M
PROVIDER: S-EPMC7954790 | biostudies-literature | 2021 Mar
REPOSITORIES: biostudies-literature
Versaevel Marie M Alaimo Laura L Seveau Valentine V Luciano Marine M Mohammed Danahe D Bruyère Céline C Vercruysse Eléonore E Théodoly Olivier O Gabriele Sylvain S
Scientific reports 20210312 1
The ability of cells to respond to substrate-bound protein gradients is crucial for many physiological processes, such as immune response, neurogenesis and cancer cell migration. However, the difficulty to produce well-controlled protein gradients has long been a limitation to our understanding of collective cell migration in response to haptotaxis. Here we use a photopatterning technique to create circular, square and linear fibronectin (FN) gradients on two-dimensional (2D) culture substrates. ...[more]