Ontology highlight
ABSTRACT:
SUBMITTER: Maione AS
PROVIDER: S-EPMC7961797 | biostudies-literature | 2021 Mar
REPOSITORIES: biostudies-literature
Maione Angela Serena AS Stadiotti Ilaria I Pilato Chiara Assunta CA Perrucci Gianluca Lorenzo GL Saverio Valentina V Catto Valentina V Vettor Giulia G Casella Michela M Guarino Anna A Polvani Gianluca G Pompilio Giulio G Sommariva Elena E
International journal of molecular sciences 20210306 5
Arrhythmogenic Cardiomyopathy (ACM) is characterized by the replacement of the myocardium with fibrotic or fibro-fatty tissue and inflammatory infiltrates in the heart. To date, while ACM adipogenesis is a well-investigated differentiation program, ACM-related fibrosis remains a scientific gap of knowledge. In this study, we analyze the fibrotic process occurring during ACM pathogenesis focusing on the role of cardiac mesenchymal stromal cells (C-MSC) as a source of myofibroblasts. We performed ...[more]