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Radiotherapy as an immune checkpoint blockade combination strategy for hepatocellular carcinoma.

ABSTRACT: In the immune oncology era, the clinical efficacy of immune checkpoint inhibitors (ICIs) against most solid cancers is well known. In hepatocellular carcinoma, the recent success of combination therapy with targeting agents has accelerated the search for novel combination strategies. Radiotherapy (RT), an attractive modality, can be combined with ICIs, which act as strong modulators of the tumor immune microenvironment. Herein, we discuss immune modulation caused by radiation and the current trials of RT-ICI combination treatment as well as future perspectives.

SUBMITTER: Lee BM

PROVIDER: S-EPMC7968135 | biostudies-literature | 2021 Mar

REPOSITORIES: biostudies-literature

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Radiotherapy as an immune checkpoint blockade combination strategy for hepatocellular carcinoma.

Lee Byung Min BM Seong Jinsil J

World journal of gastroenterology 20210301 10

In the immune oncology era, the clinical efficacy of immune checkpoint inhibitors (ICIs) against most solid cancers is well known. In hepatocellular carcinoma, the recent success of combination therapy with targeting agents has accelerated the search for novel combination strategies. Radiotherapy (RT), an attractive modality, can be combined with ICIs, which act as strong modulators of the tumor immune microenvironment. Herein, we discuss immune modulation caused by radiation and the current tri ...[more]

PMID: 33776363

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