Ontology highlight
ABSTRACT:
SUBMITTER: Fry BR
PROVIDER: S-EPMC7970740 | biostudies-literature | 2021 Apr
REPOSITORIES: biostudies-literature
Fry Benjamin R BR Pence Nathan T NT McLocklin Andrew A Johnson Alexander W AW
Learning & memory (Cold Spring Harbor, N.Y.) 20210315 4
The dopamine system has been implicated in decision-making particularly when associated with effortful behavior. We examined acute optogenetic stimulation of dopamine cells in the ventral tegmental area (VTA) as mice engaged in an effort-based decision-making task. Tyrosine hydroxylase-Cre mice were injected with Cre-dependent ChR2 or eYFP control virus in the VTA. While eYFP control mice showed effortful discounting, stimulation of dopamine cells in ChR2 mice disrupted effort-based decision-mak ...[more]