Preclinical evaluation of radiation therapy of BRCA1-associated mammary tumors using a mouse model.

ABSTRACT: Although germline mutations in BRCA1 highly predispose women towards breast and ovarian cancer, few substantial improvements in preventing or treating such cancers have been made. Importantly, BRCA1 function is closely associated with DNA damage repair, which is required for genetic stability. Here, we examined the efficacy of radiotherapy, assessing the accumulation of genetic instabilities, in the treatment of BRCA1-associated breast cancer using a Brca1-mutant mouse model. Treatment of Brca1-mutant tumor-engrafted mice with X-rays reduced tumor progression by 27.9% compared with untreated controls. A correlation analysis of irradiation responses and biomarker profiles in tumors at baseline identified differences between responders and non-responders at the pr

SUBMITTER: Cho EJ 

PROVIDER: S-EPMC7975707 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature