Dataset Information

Inhibition of mTOR attenuates the initiation and progression of BRCA1-associated mammary tumors

ABSTRACT: We conducted global proteome and phosphoproteome profiling of vehicle- and everolimus-treated tumors from 17 mice that were allografted with spontaneously developed mammary tumors from Brca1co/coMMTV-Cre mice using LC-MS/MS. The Proteome Discoverer analysis identified 9,625 proteins having two unique sibling peptides and more and 35,142 phosphopeptides with a peptide- and protein-level FDR of 1% using SEQUEST-HT algorithm. We defined everolimus-sensitive and resistant tumors based on proteome and phosphoproteome data, and identified protein and phosphopeptide signatures defining each cluster. Pathway enrichment analysis of these signatures further revealed that leukotriene-neutrophil activation pathways were upregulated in everolimus-resistant tumors.

INSTRUMENT(S): Q Exactive HF

ORGANISM(S): Mus Musculus (mouse)

TISSUE(S): Mammary Gland

SUBMITTER: Geun Hee Han

LAB HEAD: Daehee Hwang

PROVIDER: PXD054301 | Pride | 2025-01-24

REPOSITORIES: pride

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Dataset's files

Source:

			Action	DRS
	KSS_TMTpro_MS2_Global.mgf	Mgf
	KSS_TMTpro_MS2_Global.mzid.gz	Mzid
	KSS_TMTpro_MS2_Global_S01_F01.raw	Raw
	KSS_TMTpro_MS2_Global_S01_F02.raw	Raw
	KSS_TMTpro_MS2_Global_S01_F03.raw	Raw

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Publications

Inhibition of mTOR attenuates the initiation and progression of BRCA1-associated mammary tumors.

Baek Hye Jung HJ Han Geun Hee GH Cho Eun Joo EJ Xu Jihao J Ki Min Kyung MK Park Eun Jung EJ Kim Tae Hyun TH Shin Dong Hoon DH Cheong Heesun H Deng Chu-Xia CX Lim Sung Chul SC Hwang Chang-Il CI Hwang Daehee D Kim Sang Soo SS

Cancer communications (London, England) 20250118

PMID: 39826130

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