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MiR-22-3p/PGC1β Suppresses Breast Cancer Cell Tumorigenesis via PPARγ.


ABSTRACT: In this study, we found that miR-22-3p expression was decreased in breast cancer (BC) cell lines and tissues. Overexpression of miR-22-3p inhibited the proliferation and migration of BC cells in vitro and in vivo, while depletion of miR-22-3p exhibited the opposite effect. Importantly, miR-22-3p could directly target PGC1β and finally regulate the PPARγ pathway in BC. In conclusion, miR-22-3p/PGC1β suppresses BC cell tumorigenesis via PPARγ, which may become a potential biomarker and therapeutic target.

SUBMITTER: Wang X 

PROVIDER: S-EPMC7981180 | biostudies-literature |

REPOSITORIES: biostudies-literature

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