Unknown

Dataset Information

0

Studies toward the Synthesis of Amphidinolide C1: Stereoselective Construction of the C(1)-C(15) Segment.


ABSTRACT: An enantioselective synthesis of the C(1)-C(15) segment of the marine natural product amphidinolide C has been accomplished by a route that includes a stereoselective boron-Wittig reaction to furnish a trisubstituted alkenylboronate. In addition, the route employs enantioselective alkene diboration to install the C(6) hydroxyl group which undergoes intramolecular conjugate addition to establish a tetrahydrofuran ring. Lastly, a catalytic Suzuki-Miyaura cross-coupling is accomplished to construct the C(9)-C(10) bond.

SUBMITTER: Namirembe S 

PROVIDER: S-EPMC7982962 | biostudies-literature |

REPOSITORIES: biostudies-literature

Similar Datasets

| S-EPMC9207912 | biostudies-literature
| S-EPMC6641448 | biostudies-literature
| S-EPMC3763838 | biostudies-literature
| S-EPMC2896498 | biostudies-literature
| S-EPMC6269906 | biostudies-other
| S-EPMC2538580 | biostudies-literature
| S-EPMC2650083 | biostudies-literature
| S-EPMC7203982 | biostudies-literature
| S-EPMC2527052 | biostudies-literature
| S-EPMC4244837 | biostudies-literature