A Visible-Light Promoted Amine Oxidation Catalyzed by a Cp*Ir Complex.

ABSTRACT: Through a rapid screening of Cp*Ir complexes based on a turn-on type fluorescence readout, a [Cp*Ir(dipyrido[3,2-a : 2',3'-c]phenazine)Cl]⁺ complex was found to catalyze the blue-light promoted dehydrogenation of N-heterocycles under physiological conditions. In the dehydrogenation of tetrahydroisoquinolines, the catalyst preferentially yielded the monodehydrogenated product, accompanying H₂O₂ generation. We surmise that this mechanism may be reminiscent of flavin-dependent oxidases.

SUBMITTER: Davis HJ 

PROVIDER: S-EPMC7984327 | biostudies-literature |

REPOSITORIES: biostudies-literature