Antibody kinetics and clinical course of COVID-19 a prospective observational study.
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ABSTRACT: Background
Serological response and association to clinical manifestation is important for understanding the pathogenesis of COVID-19.Materials and methods
A prospective observational study was conducted where antibody responses of IgG and IgA towards SARS-CoV-2 spike protein were studied over time in patients with COVID-19. Possible associations between antibody titers and outcome were analyzed.Results
Forty patients with COVID-19, hospitalized at Skåne University hospital, Sweden, between April and June 2020 were included. IgG antibody responses were detected for all patients with the highest levels four weeks after COVID-19 diagnosis. Levels of IgA were generally higher at diagnosis and decreased towards baseline 4 weeks after confirmed COVID-19. Patients with severe COVID-19 had higher levels of antibodies directed against SARS-CoV-2 spike protein compared with patients with mild disease.Conclusion
IgG and IgA antibodies towards the spike protein follow different kinetics during COVID-19 and patients with severe disease develop higher antibody levels.
SUBMITTER: Blackberg A
PROVIDER: S-EPMC7984607 | biostudies-literature |
REPOSITORIES: biostudies-literature
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