Ontology highlight
ABSTRACT:
SUBMITTER: Gao L
PROVIDER: S-EPMC7985843 | biostudies-literature | 2020 Aug
REPOSITORIES: biostudies-literature
Gao Linyi L Altae-Tran Han H Böhning Francisca F Makarova Kira S KS Segel Michael M Schmid-Burgk Jonathan L JL Koob Jeremy J Wolf Yuri I YI Koonin Eugene V EV Zhang Feng F
Science (New York, N.Y.) 20200801 6507
Bacteria and archaea are frequently attacked by viruses and other mobile genetic elements and rely on dedicated antiviral defense systems, such as restriction endonucleases and CRISPR, to survive. The enormous diversity of viruses suggests that more types of defense systems exist than are currently known. By systematic defense gene prediction and heterologous reconstitution, here we discover 29 widespread antiviral gene cassettes, collectively present in 32% of all sequenced bacterial and archae ...[more]