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Using Adoptive Cellular Therapy for Localized Protein Secretion.

ABSTRACT:

Abstract

Redirection of T cell cytotoxicity by the chimeric antigen receptor (CAR) structure may not be sufficient for optimal antitumor function in the patient tumor microenvironment. Comodifying CAR T cells to secrete different classes of proteins can be used to optimize CAR T cell function, overcome suppressive signals, and/or alter the tumor microenvironment milieu. These modifications aim to improve initial responses to therapy and enhance the durability of response. Furthermore, CAR T cells can deliver these molecules locally to the tumor microenvironment, avoiding systemic distribution. This approach has been tested in preclinical models using a variety of different classes of agonistic and antagonistic proteins, and clinical trials are currently underway to assess efficacy in patients.

SUBMITTER: Evans AN

PROVIDER: S-EPMC7988838 | biostudies-literature | 2021 Mar-Apr 01

REPOSITORIES: biostudies-literature

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Using Adoptive Cellular Therapy for Localized Protein Secretion.

Evans Alysa N AN Lin Heather K HK Hossian A K M Nawshad AKMN Rafiq Sarwish S

Cancer journal (Sudbury, Mass.) 20210301 2

<h4>Abstract</h4>Redirection of T cell cytotoxicity by the chimeric antigen receptor (CAR) structure may not be sufficient for optimal antitumor function in the patient tumor microenvironment. Comodifying CAR T cells to secrete different classes of proteins can be used to optimize CAR T cell function, overcome suppressive signals, and/or alter the tumor microenvironment milieu. These modifications aim to improve initial responses to therapy and enhance the durability of response. Furthermore, CA ...[more]

PMID: 33750076

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